Asian Nano forum conference , 2015-03-08

Title : ( Investigating the Doxorubicin Adsorption Properties on a Magnetic Nanocomposite Containing Nonporous and Mesoporous silica Layers )

Authors: Nafishe Farhadian , saba mehrad fard , Tahere Rohani Bastami ,
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Cancer is a major public health problem all over the world. Applying chemotherapy is a common treatment of human cancers. The general systemic distribution of chemotherapeutic agent causeshuge side effects because of the drug attacks to the normal and healthy cells as well as tumour cells.Therefore, it is very important to deliverthe chemotherapeutic agents to the tumour cells efficiently. Among various methods for drug delivery, magnetic drug targeting is a drug delivery system that can be used in loco regional cancer treatment. In this study, we have been synthesized a core shell nanocmposite(〖Fe〗_3 O_4@〖nSiO〗_2@〖mSiO〗_2) to investigate the adsorption properties of doxorubicin anticancer drug. Thisnanocompositewith core-shell structure contain asuperparamagnetic iron oxide core which was synthesized by a very simple solvothermal method, a nonporous silica middle layer and an ordered mesoporous MCM-41 silica outer shell.To enhance the delivery of drug to the targeting cancer cells, and thereby decrease their toxicity to the surrounding normal tissues, the surface of the nanocompositesis functionalized with folic acid and amine group. Dynamic light scattering (DLS) analysis shows a unique particle size around 73 nm which is appropriate for drug delivery systems. The attachment of folic acid, amine andsilicato the iron oxide nanoparticleswas confirmed by using FTIR analysis.In addition, adsorption of doxorubicin anticancer drug on this synthesized nanocomposite was investigated using UV analysis. Adsorption results show that doxorubicin drug is adsorbed on 〖Fe〗_3 O_4@〖nSiO〗_2@〖mSiO〗_2nanocompositesurface with 65% efficiencyand 13% drug loading content.At last,the equilibrium isotherms were analysed using two widely used isotherm models: Langmuirand Freundlich. Error analysis, using the linear correlation coefficients (r^2), showed thatthe Langmuir isotherm best fits the adsorption data.

Keywords

, Nanocomposite; Drug delivery; Anti, cancer
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@inproceedings{paperid:1047223,
author = {Farhadian, Nafishe and Mehrad Fard, Saba and Tahere Rohani Bastami},
title = {Investigating the Doxorubicin Adsorption Properties on a Magnetic Nanocomposite Containing Nonporous and Mesoporous silica Layers},
booktitle = {Asian Nano forum conference},
year = {2015},
location = {جزیره کیش, IRAN},
keywords = {Nanocomposite; Drug delivery; Anti-cancer drug},
}

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%0 Conference Proceedings
%T Investigating the Doxorubicin Adsorption Properties on a Magnetic Nanocomposite Containing Nonporous and Mesoporous silica Layers
%A Farhadian, Nafishe
%A Mehrad Fard, Saba
%A Tahere Rohani Bastami
%J Asian Nano forum conference
%D 2015

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