Iranian Journal of Veterinary Science and Technology, Volume (5), No (2), Year (2013-12) , Pages (19-32)

Title : ( Histopathological evaluation of the effect of platelet-rich fibrin on canine cutaneous incisional wound healing )

Authors: Majid Khanzadeh Alishahi , Davoud Kazemi , Darioush Mohajeri , Hasan Mofidpoor , Amir Afkhami Goli , Mohamad Ali Khanzadeh Alishahi ,

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Abstract

Platelets are a natural source of growth factors and cytokines that promote wound healing, and platelet-rich fibrin contains concentrated growth factors. Growth factors in platelet-rich fibrin may promote wound repair. In this study the effect of platelet-rich fibrin was evaluated in a dog model of cutaneous incisional wounds using histology and semi-quantitative evaluation. One pair of ten-centimeter full-thickness parallel linear cutaneous wounds were created on the backs of 15 dogs on the both sides of vertebral column. On the left side the platelet-rich fibrin clot was applied to the edges of the wound (Treatment group) and the right side received nothing (Control group). All wounds were then closed with 3-0 non-absorbable Nylon suture. The dogs were divided into three groups of five dogs. The wound tissues were sampled by electrosurgery in group one after 3 days, group two after 7 days and group three after 14 days post surgery. For each specimen, histopathological examination and semiquantitative evaluation was performed by light microscopy using Hematoxylin & Eosin and Masson’s trichrome staining. The results demonstrated that platelet-rich fibrin improved and accelerated cutaneous incisional wound healing.

Keywords

, Platelet-rich fibrin, wound healing, cutaneous wound
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@article{paperid:1054802,
author = {Majid Khanzadeh Alishahi and Davoud Kazemi and Darioush Mohajeri and Hasan Mofidpoor and Afkhami Goli, Amir and Mohamad Ali Khanzadeh Alishahi},
title = {Histopathological evaluation of the effect of platelet-rich fibrin on canine cutaneous incisional wound healing},
journal = {Iranian Journal of Veterinary Science and Technology},
year = {2013},
volume = {5},
number = {2},
month = {December},
issn = {2008-465X},
pages = {19--32},
numpages = {13},
keywords = {Platelet-rich fibrin; wound healing; cutaneous wound},
}

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%0 Journal Article
%T Histopathological evaluation of the effect of platelet-rich fibrin on canine cutaneous incisional wound healing
%A Majid Khanzadeh Alishahi
%A Davoud Kazemi
%A Darioush Mohajeri
%A Hasan Mofidpoor
%A Afkhami Goli, Amir
%A Mohamad Ali Khanzadeh Alishahi
%J Iranian Journal of Veterinary Science and Technology
%@ 2008-465X
%D 2013

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