Title : ( Synthesis, Characterisation, and in Vitro Antibacterial Evaluation of a New Class of 2-substituted-4-methyl-7,8-dihydro-5H-pyrimido[4,5-d]thiazolo[3,2-a] Pyrimidines )
Authors: yasaman etemadi , Ali Shiri , Hossein Eshghi , marzieh akbarzadeh , Kayvan Saadat , sarina sadat mozafari , Hamid Beyzaei , Mohammadreza Moghaddam-Manesh ,
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Abstract
The reaction of 2,4-dichloro-5-(chloromethyl)-6-methylpyrimidine with 4,5-dihydrothiazol-2-amine in chloroform led to the formation of 2-chloro-4-methyl-7,8-dihydro-5H-pyrimido[4,5-d]thiazolo[3,2-a]pyrimidine (3). The true structure of the target compound was confirmed by density functional theory calculations of condensed Fukui indices. The substitution of the 2-Cl function in compound 3 with different secondary amines yielded 2-substituted-4-methyl-7,8-dihydro-5 H-pyrimido[4,5-d]thiazolo[3,2-a]pyrimidines in good yields. The assigned products were tested for their potential antibacterial activity and the results indicated that a few derivatives are valuable compounds with great potential to be used as antibacterial agents.
Keywords
, heterocyclisation, pyrimido[4, 5-d]thiazolo[3, 2-a]pyrimidine, DFT, Fukui indices, antibacterial evaluation
@article{paperid:1058716,
author = {Etemadi, Yasaman and Shiri, Ali and Eshghi, Hossein and Akbarzadeh, Marzieh and Saadat, Kayvan and Mozafari, Sarina Sadat and Hamid Beyzaei and Mohammadreza Moghaddam-Manesh},
title = {Synthesis, Characterisation, and in Vitro Antibacterial Evaluation of a New Class of 2-substituted-4-methyl-7,8-dihydro-5H-pyrimido[4,5-d]thiazolo[3,2-a] Pyrimidines},
journal = {Journal of Chemical Research},
year = {2016},
volume = {40},
number = {10},
month = {October},
issn = {1747-5198},
pages = {600--603},
numpages = {3},
keywords = {heterocyclisation; pyrimido[4;5-d]thiazolo[3;2-a]pyrimidine; DFT; Fukui indices; antibacterial evaluation},
}
%0 Journal Article
%T Synthesis, Characterisation, and in Vitro Antibacterial Evaluation of a New Class of 2-substituted-4-methyl-7,8-dihydro-5H-pyrimido[4,5-d]thiazolo[3,2-a] Pyrimidines
%A Etemadi, Yasaman
%A Shiri, Ali
%A Eshghi, Hossein
%A Akbarzadeh, Marzieh
%A Saadat, Kayvan
%A Mozafari, Sarina Sadat
%A Hamid Beyzaei
%A Mohammadreza Moghaddam-Manesh
%J Journal of Chemical Research
%@ 1747-5198
%D 2016
