Background: Improvements in nanotechnology in the past decayed has created variousopportunities for evaluation of biologic effects such as antibacterial and antifungal effects of nanoparticles. Silver nanoparticles have recently attracted much interest due to their distinct properties and potential applications in various fields especially biomedical [1-3]. Methods: Nanocrystalline NiFe2O4 samples were prepared by hydrothermal method. The synthesis process was accomplished by metal chloride precursors in ethylene glycol in presence of sodium acetate and ethanolamine. Silver ions were loaded onto the surface of the modified NiFe2O4 and reduced to silver crystal by adding NaBH4. NiFe2O4@Ag sample was tested for their antibacterial activity against Pseudomonas syringe and Bacillus subtilis and antifungal activity against Alternaria solani and Fusarium oxysporum, respectively. Biological results indicated that the synthesized materials have shown an excellent antibacterial and antifungal activity against both of bacteria and fungi, which their growth were completely inhibited after 24 h contact with NiFe2O4@Ag. Results: The final products were thoroughly characterized by Fourier Transform Infrared Spectroscopy (FT-IR), X-ray powder diffraction (XRD), Field Emission Scanning Electron Microscopy (FE-SEM) along with Energy Dispersive X-ray (EDX) Spectroscopy and thermogravimetric and differential thermal analysis (TG/DTA). Conclusion: Use of NiFe2o4@Ag nanoparticles as an anti microbial agent is recommended in different fields of medicine, food industry and agriculture and can be of importance considering health and economic issues.

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