2nd International and 10th National Biotechnology Congress , 2017-08-29

عنوان : ( Investigating Cytotoxic and Anticancer Properties of pyridinedicarboxylato Ag(I) Complex on HeLa Cervical Cancer Cells )

نویسندگان: سیدحسین سیدمرادی , احمدرضا بهرامی , مسعود میرزائی شهرابی , مریم مقدم متین ,
فایل: Full Text

استناددهی: BibTeX | EndNote

چکیده

Cervical cancer is the fourth most common cancer among women, and the seventh overall most common cancer in the world. In cervical cancer, chemotherapy is considered as the first-line treatment. This procedure is effectively done with platinum complexes, although chemotherapy with cisplatin and its analogues still suffers from several drawbacks. As a result, it provides the impetus for the development of new metal complexes with better anticancer activity potential. In this study, we investigated the cytotoxic effects and anticancer activity of Ag pyridine complex on cervical cancer (HeLa) and normal (HDF) cell lines for the fist time. To do so, cells were treated with various concentrations of this compound for 24, 48 and 72 hours. Then, cell viability was evaluated by MTT assay. The results of the MTT assay showed that pyridinedicarboxylato Ag(I) complex had cytotoxic effects on HeLa cells with IC value of about 5 μg/ml after 48 hours of treatment. Moreover, IC 50 value of cisplatin was 50 approximately 2 μg/ml after 48 hours of treatment. In addition, the results indicated that pyridinedicarboxylato Ag(I) complex had lower cytotoxic effects on normal HDF cells with IC 50 values of about 13, 17 and 10 μg/ml after 24, 48 and 72 hours of treatment, respectively. The results indicate that understanding of structure–activity relationship is considered as a prospective investigation so as to find a more effective drug compered to cisplatin.

کلمات کلیدی

, Anti-cancer Drugs, Cytotoxic Agents, Silver Metal Complexes, HeLa cell Line , HDF Cell Line
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@inproceedings{paperid:1064569,
author = {سیدمرادی, سیدحسین and بهرامی, احمدرضا and میرزائی شهرابی, مسعود and مقدم متین, مریم},
title = {Investigating Cytotoxic and Anticancer Properties of pyridinedicarboxylato Ag(I) Complex on HeLa Cervical Cancer Cells},
booktitle = {2nd International and 10th National Biotechnology Congress},
year = {2017},
location = {کرج, ايران},
keywords = {Anti-cancer Drugs; Cytotoxic Agents; Silver Metal Complexes; HeLa cell Line ،HDF Cell Line},
}

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%0 Conference Proceedings
%T Investigating Cytotoxic and Anticancer Properties of pyridinedicarboxylato Ag(I) Complex on HeLa Cervical Cancer Cells
%A سیدمرادی, سیدحسین
%A بهرامی, احمدرضا
%A میرزائی شهرابی, مسعود
%A مقدم متین, مریم
%J 2nd International and 10th National Biotechnology Congress
%D 2017

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