Title : ( Regioselective synthesis of new 5H,10H-dipyrimido[2,1-b:4′,5′-d][1,3]thiazine: a combined experimental and computational study )
Authors: Toktam Afrough , Mehdi Bakavoli , Hossein Eshghi , javad tajabadi , Joel Mague ,
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Abstract
Several derivatives of the novel tricyclic system ‘dipyrimido[2,1- b:4,5-d][1,3]thiazine’ were synthesized via inter- and intramolecular heterocyclization of 2,4-dichloro-5--chloromethyl--6-methylpyrimidine and 6-amino-4-aryl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5- carbonitrile in short reaction times under mild conditions. An x-ray analysis together with computational calculations was performed to gain an in-depth understanding of regioselectivity of the reaction.
Keywords
, Dipyrimido[2, 1-b:4, 5-d] [1, 3]thiazine; heterocyclization; regioselectivity; computational calculations
@article{paperid:1074100,
author = {Afrough, Toktam and Bakavoli, Mehdi and Eshghi, Hossein and Tajabadi, Javad and Joel Mague},
title = {Regioselective synthesis of new 5H,10H-dipyrimido[2,1-b:4′,5′-d][1,3]thiazine: a combined experimental and computational study},
journal = {Journal of Sulfur Chemistry},
year = {2019},
volume = {40},
number = {3},
month = {May},
issn = {1741-5993},
pages = {265--276},
numpages = {11},
keywords = {Dipyrimido[2;1-b:4;5-d]
[1;3]thiazine;
heterocyclization;
regioselectivity;
computational calculations},
}
%0 Journal Article
%T Regioselective synthesis of new 5H,10H-dipyrimido[2,1-b:4′,5′-d][1,3]thiazine: a combined experimental and computational study
%A Afrough, Toktam
%A Bakavoli, Mehdi
%A Eshghi, Hossein
%A Tajabadi, Javad
%A Joel Mague
%J Journal of Sulfur Chemistry
%@ 1741-5993
%D 2019
