Stem Cells International, Volume (2016), Year (2016-1) , Pages (1-12)

Title : ( Lavandula angustifoliaExtract Improves the Result of Human Umbilical Mesenchymal Wharton’s Jelly Stem Cell Transplantation after Contusive Spinal Cord Injury in Wistar Rats )

Authors: Kayvan Yaghoobi , Gholamreza Kaka , Korosh Mansouri , Shaghayegh Davoodi , Seyed Homayoon Sadraie , Seyed Ruhollah Hosseini ,

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Abstract

Introduction. The primary trauma of spinal cord injury (SCI) results in severe damage to nervous functions. At the cellular level, SCI causes astrogliosis. Human umbilical mesenchymal stem cells (HUMSCs), isolated from Wharton’s jelly of the umbilical cord, can be easily obtained. Previously, we showed that the neuroprotective effects of Lavandula angustifolia can lead to improvement in a contusive SCI model in rats. Objective. The aim of this study was to investigate the effect of L. angustifolia (Lav) on HUMSC transplantation after acute SCI. Materials and Methods. Sixty adult female rats were randomly divided into eight groups. Every week after SCI onset, all animals were evaluated for behavior outcomes. H&E staining was performed to examine the lesions after injury. GFAP expression was assessed for astrogliosis. Somatosensory evoked potential (SEP) testing was performed to detect the recovery of neural conduction. Results. Behavioral tests showed that the HUMSC group improved in comparison with the SCI group, but HUMSC + Lav 400 was very effective, resulting in a significant increase in locomotion activity. Sensory tests and histomorphological and immunohistochemistry analyses verified the potentiation effects of Lav extract on HUMSC treatment. Conclusion. Transplantation of HUMSCs is beneficial for SCI in rats, and Lav extract can potentiate the functional and cellular recovery with HUMSC treatment in rats after SCI.

Keywords

, Lavandula angustifolia, f Human Umbilical Mesenchymal Wharton’s Jelly Stem Cell, Spinal Cord Injury
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@article{paperid:1081170,
author = {Kayvan Yaghoobi and Gholamreza Kaka and Korosh Mansouri and Shaghayegh Davoodi and Seyed Homayoon Sadraie and Hosseini, Seyed Ruhollah},
title = {Lavandula angustifoliaExtract Improves the Result of Human Umbilical Mesenchymal Wharton’s Jelly Stem Cell Transplantation after Contusive Spinal Cord Injury in Wistar Rats},
journal = {Stem Cells International},
year = {2016},
volume = {2016},
month = {January},
issn = {1687-966X},
pages = {1--12},
numpages = {11},
keywords = {Lavandula angustifolia; f Human Umbilical Mesenchymal Wharton’s Jelly Stem Cell; Spinal Cord Injury},
}

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%0 Journal Article
%T Lavandula angustifoliaExtract Improves the Result of Human Umbilical Mesenchymal Wharton’s Jelly Stem Cell Transplantation after Contusive Spinal Cord Injury in Wistar Rats
%A Kayvan Yaghoobi
%A Gholamreza Kaka
%A Korosh Mansouri
%A Shaghayegh Davoodi
%A Seyed Homayoon Sadraie
%A Hosseini, Seyed Ruhollah
%J Stem Cells International
%@ 1687-966X
%D 2016

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