@inproceedings{paperid:1035428,
author = {Sheikhi Mohammareh, Seddigheh and Rahimizadeh, Mohammad and Bakavoli, Mehdi and Shiri, Ali},
title = {A facile approach for the synthesis of new derivatives of pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidine},
booktitle = {20th Iranian Seminar of Organic Chemistry},
year = {2013},
location = {همدان, IRAN},
keywords = {Pyrazolotriazolopyrimidines are a class of fused heterocycles which have interesting pharmacological activities[1]. Several 3- and/or 5-substituted 7H-pyrazolo[4;3-e][1;2;4]triazolo[4;3c]pyrimidines were reported to be potent xanthine oxidase (XO) inhibitors[2].In addition; various derivatives of them have been used as a new pharmacological tool for characterization of human A
3
adenosine receptors[3]. Initially; pyrazolo[3;4-d]pyrimidine (1) was prepared according to previous published method[4] 
and subsequently treated with POCl
 and hydrazine hydrate to give the desired compound (2). In continuation; the heterocyclization reaction of compound (2) with some triethylorthoesters in boiling acetic acid gave quantitatively the corresponding new pyrazolotriazolopyrimidine derivatives (3a-c). On the other hand; the reaction of compound (2) with CS
3
 in DMF and then various alkylhalides yeilded the new derivatives of pyrazolotriazolopyrimidine (4a-e) in good yields. 
2},
}