@inproceedings{paperid:1035432,
author = {Karimian, Azam and Rahimizadeh, Mohammad and Eshghi, Hossein and Bakavoli, Mehdi},
title = {Synthesis of new derivatives ofdipyrimido[4,5-b:5,4-e][1,4]thiazine and their enzyme inhibitory activity assessment on soybean 15-lipoxygenase},
booktitle = {20th Iranian Seminar of Organic Chemistry},
year = {2013},
location = {همدان, IRAN},
keywords = {Pyrimidine derivatives and annulated pyrimidines continue to attract great interest because of their wide variety of interesting biological activities; such as anticancer [1]; antiviral [2]; antitumor [3]; and anti-inflammatory activities [4].  
Continuing our perivious work [5]; In this study we decided to synthesise a new fused pyrimidine ring system dipyrimido[4;5-b:5;4-e][1;4]thiazine and study its biological activities. For this purpose we first prepared compound (1) and (2).  
Reaction of compound (1) with (2) in the presence of Et
N in boiling EtOH gave quantitatively the desired compound (3). The subsequent treatment of compound (3) with various secondary amines in DMF gave the cyclized products 4(a-f) in good yields (Scheme 1). Consequently; the enzyme inhibitory activities of these compouns on soybean 15-lipoxygenase (15-LO) are also evaluated. 
3},
}