@inproceedings{paperid:1035435, author = {Eshghi, Hossein and Mirzaei, Mehdi and Rahimizadeh, Mohammad}, title = {A novel and efficient one-pot synthesis of new α-aminophosphonates and evaluation of their biologicalactivities}, booktitle = {20th Iranian Seminar of Organic Chemistry}, year = {2013}, location = {همدان, IRAN}, keywords = {In recent years; considerable interest has been focused on the synthesis of α-aminophosphonates; because they are considered to be structural analogues of the corresponding α-aminoacids.In these connections; the utilities of α-aminophosphonates as anticancer; antibiotics and pharmacologic agents [1-2]. The synthesis of some novel α-aminophosphonates throughan addition of diethyl phosphite to electro-rich aldehyde and different amines[3]. This study represents a three-componentreaction in which no intermediate formation of either an imine or α-hydroxyphosphonate was observed. In this protocol avoids the use of any catalyst; any solvents; and dry reaction conditions.The aaminophosphonates have been characterized by elemental analysis; IR and NMR ( 1 H; 13 C and 3 1P) spectra and X-ray diffraction. Some of these α-aminophosphonates were found to have antitumor activity on the cell lines DU145 in vitro by the MTT method.(Scheme 1)}, }