@inproceedings{paperid:1035437, author = {Javadian Saraf, Aida and Eshghi, Hossein and Rahimizadeh, Mohammad and Hasanpour Mansour, Maede}, title = {Synthesis of new pyrimido[4,5-d]pyrimidin-4(1H)-one derivatives in the presence of ferric hydrogensulfate}, booktitle = {20th Iranian Seminar of Organic Chemistry}, year = {2013}, location = {همدان, IRAN}, keywords = {Pyrimidopyrimidines are bicyclic uracils that have attracted considerable interest in recent years [1]. Their derivatives have been known to display a wide range of pharmacological activities; and potent inhibitory properties. Numerous reports explain the antitumor;antiviral;antioxidant; antifungal; antiallergic; antihypertensive activities of these compounds [2-3]. In this report new derivatives of pyrimido[4;5-d]pyrimidine have been synthesized in a threecomponent; efficient and green process by condensation reaction of 6-amino-thiouracil; aldehydes and urea or thiourea or guanidine in the presence of ferric hydrogensulfate as catalyst in ethanol under reflux condition.The advantages of this method are high conversion and yield; simple experimental and workup procedure (Scheme 1).}, }