@inproceedings{paperid:1070299,
author = {Younesi Soltani, Fatemeh and Parham, Abbas and },
title = {Tenogenic Differentiation Potential of Adipose-Derived Mesenchymal Stem Cells},
booktitle = {3rd International and th National Congress of Wound Healing and Tissue Repair},
year = {2018},
location = {تهران, IRAN},
keywords = {Mesenchymal stem cells (MSCs) have potential applications in regenerative
medicine and tissue engineering and may represent an attractive option for
tendon repair and regeneration. Additionally; adipose tissue yields a high
number of Adipose-derived Mesenchymal Stem Cells (AMSC) per volume of
tissue. Tendinitis and degenerative diseases of flexor tendons are common and
debilitating musculoskeletal conditions in equine athletes. In horses with
tendinitis; peptide; cell; or small-molecule therapies are used in attempts to
decrease the high incidence of recurrence and bolster the limited intrinsic
tendon repair capacity. Tendon healing is generally slow and involves a wide
range of molecules in a complex but regulated mechanism. Exogenous agents
that positively influence any of these phases may be of major therapeutic value
in tendon repair. To promote and support tendon healing; one viable strategy is
the use or administration of growth factors at the wound/rupture site. Plateletenriched plasma concentrates have also emerged as useful agents; supplying an
array of growth factors including PDGF; IGF-I; TGF-β ; and; in smaller
amounts; EGF; VEGF; hepatocyte growth factor; and basic fibroblastic growth
factor. Despite the interest in PDGF as a therapeutic option for tendon healing;
there is little compelling evidence to confirm that PDGF induces cell
proliferation and matrix production in tendon samples. Growth factors (GFs)
such as EGF; FGF; PDGF and TGF-b participate in tendon formation; ECM
synthesis or healing; and may assist tenogenic differentiation. Experiments
were performed with and without growth factors (IGF‐ ; TGF‐β ; IGF‐ /TGF‐
β ; PDGF‐BB; and BMP‐ ); in co‐cultures of tenocytes and MSCs mixed in
different ratios and by culturing MSCs with spent media obtained from primary
tenocytes. This review aims to summarize the strategies currently used for
differentation of MSCs to tenocytes as well as their advantages and limitations;
and factors affecting tenogenic differentiation were summarized.},
}