Abstract: Scaffolds require individual external shapes and well-defi ned internal structures with interconnected porosity to host most cell types. From a biological point of view, the designed matrix should serve various functions, including: 1) as an immobilization site for transplanted cells; 2) forming a protective space to prevent unwanted tissue growth into the wound bed and allow healing with differentiated tissue; 3) directing migration or growth of cells via surface properties of the scaffold; and 4) directing the migration or growth of cells via the release of soluble molecules such as growth factors, hormones, and/or cytokines. Some technology platforms of Food and Drug Administration (FDA)–approved polymeric degradable scaffold systems have already found promising clinical applications.