The 10th Conference on Biochemical Engineering , 2005-06-24

Title : ( Metabolic Organization of Caenorhabditis elegans )

Authors: Mahmood Akhavan Mahdavi , Yen-Han Lin ,

Citation: BibTeX | EndNote

Metabolic bionetwork of Caenorhabditis elegans has been reconstructed using genome information retrieved from KEGG (Kyoto Encyclopedia of Genomes and Genes, Release 32) database. The reconstructed bionetwork contains 103 pathways and 22272 open reading frames comprising 21357 protein genes (coding sequences) and 753 RNA genes. As of November 2004, 990 genes are assigned with pathway as-sociation, among which, 561 genes are localized in single pathways whereas 429 genes, so called key enzymes, exhibit multiple pathway association. Key enzymes contribute to the interconnecting behaviour of the reconstructed bionetwork and con-nect different pathways together, termed as ‘functionally linked’, to accomplish a bio-logical task. These links are perceived through interception of key enzymes in the vis-ual representation of the reconstructed bionetwork. Key enzymes’ participation in pathways ranges from 2 to 15 pathways. In order to visualize the interconnectedness of the reconstructed bionetwork Pajek tool was used. Reconstruction process revealed that, 990 known genes perform 2024 distinct biological functions, mostly metabolic functions and partly signalling and regulation. Metabolic pathways are involved in biosynthesis and biodegradation of key compounds such as ATP to provide energy for cell operations.

Keywords

, Bionetwork reconstruction, Genome organization, genome database, Caenorhabditis elegans, Key
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@inproceedings{paperid:1007129,
author = {Akhavan Mahdavi, Mahmood and Yen-Han Lin},
title = {Metabolic Organization of Caenorhabditis elegans},
booktitle = {The 10th Conference on Biochemical Engineering},
year = {2005},
location = {تایپه},
keywords = {Bionetwork reconstruction; Genome organization; genome database; Caenorhabditis elegans; Key enzymes.},
}

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%0 Conference Proceedings
%T Metabolic Organization of Caenorhabditis elegans
%A Akhavan Mahdavi, Mahmood
%A Yen-Han Lin
%J The 10th Conference on Biochemical Engineering
%D 2005

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