The 8th International Conference on Chemical & Process Engineering , 2007-06-24

Title : ( Optimal control of particle size in antisolvent crystallization operations )

Authors: Seyed Mostafa Nowee Baghban , Ali Abbas , Jose Romagnoli ,

Citation: BibTeX | EndNote

In this paper we present a detailed antisolvent crystallization model. A population balance approach is adopted to describe the dynamic change of particle size in crystallization processes under the effect of antisolvent addition. The sodium chloride-water-ethanol is used as a model system. Maximum likelihood method is used to identify the nucleation and growth kinetic models for sodium chloride from data derived from controlled experiments. A number of growth and nucleation kinetic models are investigated in the estimation step to identify one with better prediction. The model is then validated under a new ethanol (antisolvent) addition profile showing to be in good agreement. The resulting model is then exploited in model-based optimization to readily develop optimal antisolvent feeding recipes. Two objective functions are used related to the control of particle size. Different feeding profiles are readily determined for different end-product particle size targets. The dynamic optimization results are successfully validated experimentally showing very close agreement. The approach presented here is rapid and repeatable and thus attractive for pharmaceutical and fine chemicals antisolvent crystallization operations aimed at control of particle size.

Keywords

, Optimal control, Particle Size, Antisolvent
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@inproceedings{paperid:1007549,
author = {Nowee Baghban, Seyed Mostafa and Ali Abbas and Jose Romagnoli},
title = {Optimal control of particle size in antisolvent crystallization operations},
booktitle = {The 8th International Conference on Chemical & Process Engineering},
year = {2007},
location = {ISCHIA, ITALY},
keywords = {Optimal control; Particle Size; Antisolvent Crystallization},
}

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%0 Conference Proceedings
%T Optimal control of particle size in antisolvent crystallization operations
%A Nowee Baghban, Seyed Mostafa
%A Ali Abbas
%A Jose Romagnoli
%J The 8th International Conference on Chemical & Process Engineering
%D 2007

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