Title : ( Acute Restraint Stress Increases the Frequency of Vinblastin- induced Micronuclei in Mouse Bone Morrow Cells )
Authors: Amir Mohammad Malvandi , Farhang Haddad , Ali Moghimi ,
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Abstract
Acute physiological stress induces remarkable effects on the nervous, endocrine, and immune systems and also on cellular metabolism and cell division processes. Stress-induced instability of cellular mechanisms might play an important role in increasing cell division disorders. In this study, a relationship between stress and micronucleus (MN) induction in mouse (balb/c) bone marrow cells following vinblastine treatment, or stress or stress and vinblastine treatment in comparison to a non-stressed control group was investigated. In order to test the effects of treatments on MN induction, an in vivo MN assay was performed on bone marrow cells. The results revealed a significantly greater increase in MNs in bone marrow cells (polychromatic erythrocytes) from the stressed/vinblastine treated mice. The data indicate the ability of exposure to an emotional stressor to enhance the damaging actions on bone marrow cells of an aneugenic agent.
Keywords
Acute restraint stress
@article{paperid:1011714,
author = {Malvandi, Amir Mohammad and Haddad, Farhang and Moghimi, Ali},
title = {Acute Restraint Stress Increases the Frequency of Vinblastin- induced Micronuclei in Mouse Bone Morrow Cells},
journal = {Stress-The International Journal on the Biology of Stress},
year = {2010},
volume = {13},
number = {3},
month = {January},
issn = {1025-3890},
pages = {276--280},
numpages = {4},
keywords = {Acute restraint stress},
}
%0 Journal Article
%T Acute Restraint Stress Increases the Frequency of Vinblastin- induced Micronuclei in Mouse Bone Morrow Cells
%A Malvandi, Amir Mohammad
%A Haddad, Farhang
%A Moghimi, Ali
%J Stress-The International Journal on the Biology of Stress
%@ 1025-3890
%D 2010
