Title : ( Regioselective Synthesis of New 2-(E)-Cyano(thiazolidin-2-ylidene)thiazoles )
Authors: Mehdi Bakavoli , , Mohammad Rahimizadeh , Hossein Eshghi , Reza Takjoo ,
Full TextAbstract
Cyclocondensation of 2-[bis(methylthio)methylene]malononitrile (1) and cysteamine (2) afforded 2-(thiazolidin-2-ylidene)malononitrile (3). This compound on treatment with NaSH gave the corresponding thioamide derivative 4a in a regioselective manner on the basis of its single crystal X-ray diffraction analysis. Reaction of this compound with several α-bromocarbonyl compounds gave new 2-(E)-cyano(thiazolidin-2- ylidene)thiazoles 5a-g.
Keywords
, thiazole; thiazolidine; Hantzsch’s synthesis; heterocyclization; regioselective synthesis; X, ray crystallography Introduction
@article{paperid:1013070,
author = {Bakavoli, Mehdi and , and Rahimizadeh, Mohammad and Eshghi, Hossein and Takjoo, Reza},
title = {Regioselective Synthesis of New 2-(E)-Cyano(thiazolidin-2-ylidene)thiazoles},
journal = {Molecules},
year = {2009},
volume = {14},
number = {10},
month = {October},
issn = {1420-3049},
pages = {4849--4859},
numpages = {10},
keywords = {thiazole; thiazolidine; Hantzsch’s synthesis; heterocyclization; regioselective
synthesis; X-ray crystallography
Introduction},
}
%0 Journal Article
%T Regioselective Synthesis of New 2-(E)-Cyano(thiazolidin-2-ylidene)thiazoles
%A Bakavoli, Mehdi
%A ,
%A Rahimizadeh, Mohammad
%A Eshghi, Hossein
%A Takjoo, Reza
%J Molecules
%@ 1420-3049
%D 2009
