ABSTRACT There has been a considerable and continuous interest to develop equations for rapid and accurate prediction of the ME of meat and bone meal. In this study, an artificial neural network (ANN), a partial least squares (PLS), and a multiple linear regression (MLR) statistical method were used to predict the TMEn of meat and bone meal based on its CP, ether extract, and ash content. The accuracy of the models was calculated by R2 value, MS error, mean absolute percentage error, mean absolute deviation, bias, and Theil’s U. The predictive ability of an ANN was compared with a PLS and a MLR model using the same training data sets. The squared regression coefficients of prediction for the MLR, PLS, and ANN models were 0.38, 0.36, and 0.94, respectively. The results revealed that ANN produced more accurate predictions of TMEn as compared with PLS and MLR methods. Based on the results of this study, ANN could be used as a promising approach for rapid prediction of nutritive value of meat and bone meal

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