Diabetes is a methabolic disease characterized by hyperglycemia, with high morbidity and mortility worldwide. Diabetic microvasular complications, which are considered as an important group of hyperglycemia imperfections, caused by increased endothelial permeability and can progress to severe impairments in several organs. Although diabetic nephropathy, neuropathy and retinopathy are the most common microvascular complications of hyperglycemia, it also affected choroid plexus. Here we briefly reviewed the characteristic and etiology of these complications emphasizing on cerebrospinal fluid.

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