Title : ( Synthesis and anticancer evaluation of new derivatives of 3-phenyl-1,5- dimethyl-1H-[1,2,4]triazolo[4’,3’:1,2]pyrimido[4,5-e][1,3,4]oxadiazine )
Authors: Mehdi Bakavoli , Mohammad Rahimizadeh , Ali Shiri , Marzieh Akbarzadeh , Seyed-Hadi Mousavi , Hoda Atapour-Mashhad , Zahra Tayarani-Najaran ,
Full TextAbstract
The synthesis of new derivatives of 3-phenyl-1,5-dimethyl-1H-[1,2,4]triazolo[4’,3’:1,2]pyrimido[4,5-e][1,3,4]oxadiazines 5a–e and 7a–e is described through heterocyclisation of hydrazino derivative (3) with aromatic aldehydes or carbon disulfide and alkyl halides. [(1,5-Dimethyl-3-phenyl-1H-[1,2,4]triazolo[4’,3’:1,2]pyrimido[4,5-e][1,3,4]oxadiazin-7-yl) sul fanyl]methyl cyanide was singled out to be tested on different cancer cell lines including HeLa, MCF-7, and HepG2. Malignant cells were cultured in DMEM medium and incubated with different concentrations of the titled compounds. Cell viability was quantified by MTT assay.
Keywords
, triazolopyrimidooxadiazine, heterocyclisation, anti-cancer, HeLa, MCF-7, HepG2
@article{paperid:1016798,
author = {Bakavoli, Mehdi and Rahimizadeh, Mohammad and Shiri, Ali and Akbarzadeh, Marzieh and Seyed-Hadi Mousavi and Hoda Atapour-Mashhad and Zahra Tayarani-Najaran},
title = {Synthesis and anticancer evaluation of new derivatives of 3-phenyl-1,5- dimethyl-1H-[1,2,4]triazolo[4’,3’:1,2]pyrimido[4,5-e][1,3,4]oxadiazine},
journal = {Journal of Chemical Research},
year = {2010},
volume = {34},
number = {7},
month = {June},
issn = {1747-5198},
pages = {403--406},
numpages = {3},
keywords = {triazolopyrimidooxadiazine; heterocyclisation; anti-cancer; HeLa; MCF-7; HepG2},
}
%0 Journal Article
%T Synthesis and anticancer evaluation of new derivatives of 3-phenyl-1,5- dimethyl-1H-[1,2,4]triazolo[4’,3’:1,2]pyrimido[4,5-e][1,3,4]oxadiazine
%A Bakavoli, Mehdi
%A Rahimizadeh, Mohammad
%A Shiri, Ali
%A Akbarzadeh, Marzieh
%A Seyed-Hadi Mousavi
%A Hoda Atapour-Mashhad
%A Zahra Tayarani-Najaran
%J Journal of Chemical Research
%@ 1747-5198
%D 2010
