It has been shown that caloric restriction has beneficial effects on different diseases. Herein, we assessed the probable effects of short-term repeated fasting on peptic ulcer induced by HCl in mice. Forty female mice were randomly divided into 2 groups. 20 mice as test and 20 mice as control. Mice in test group were subjected to a 4 steps of 4 days (with 10 day intervals) of diet restriction. Then 0.3, 0.6 and 0.9 cc of HCl (0.6N) were administrated intragastrically on both control and test groups. The macroscopic and microscopic comparison between the test and control mice showed less severe gastric damage, hemorrhage and a lower score in mice of test group. There was significant difference between mice that received 0.3 and 0.6 cc of HCl. It seems that caloric restriction can modify the harmful effects of HCl on gastric mucosa and could reduce the progression of the gastric ulcer.

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