دومین کنگره بین المللی سندرم متابولیک، چاقی و دیابت , 2010-06-16

Title : ( Study of A98V polymorphism in 100 patients with Type 2 diabetes in Mashhad population )

Authors: , Samaneh Sepahi , Razieh Jalal , Jamshid Darvish ,

Access to full-text not allowed by authors

Citation: BibTeX | EndNote

Abstract

This study was undertaken to investigate the frequency of the HNF-1α A98V mutation in Mashhad population with RFLP-PCR. The genomic DNA of 41 patients with onset diabetes ≤35 (male/female: 12/29) , 59 patients with onset diabetes ≥35 years (male/female: 22/37), and fifty normal individuals (male/female: 47/13) was extracted and the exon 1 of human HNF-1α gene was amplified . The PCR products of exon 1 were digested by HaeIII restriction endonuclease and analyzed on the agarose gel. We identified four patients (9.7%) in the early-onset type 2 diabetes group carrying heterozygote mutations in exon 1 of the HNF-1 alpha gene (Ala98Val). Our study has demonstrated that Ala98Val plays a significant role in afflicting Iranian youth to diabetes. Therefore, we suggest that MODY3 mutation should be studied more seriously in diabetic patients.

Keywords

, Ala98Val Polymorphism, Hepatocyte nuclear factor 1-α gene, Mashhad population, Type-2 Diabetes
برای دانلود از شناسه و رمز عبور پرتال پویا استفاده کنید.

@inproceedings{paperid:1018681,
author = {, and Sepahi, Samaneh and Jalal, Razieh and Darvish, Jamshid},
title = {Study of A98V polymorphism in 100 patients with Type 2 diabetes in Mashhad population},
booktitle = {دومین کنگره بین المللی سندرم متابولیک، چاقی و دیابت},
year = {2010},
location = {زنجان, IRAN},
keywords = {Ala98Val Polymorphism; Hepatocyte nuclear factor 1-α gene; Mashhad population; Type-2 Diabetes},
}

[Download]

%0 Conference Proceedings
%T Study of A98V polymorphism in 100 patients with Type 2 diabetes in Mashhad population
%A ,
%A Sepahi, Samaneh
%A Jalal, Razieh
%A Darvish, Jamshid
%J دومین کنگره بین المللی سندرم متابولیک، چاقی و دیابت
%D 2010

[Download]