Journal of Equine Veterinary Science, ( ISI ), Volume (25), No (6), Year (2005-2) , Pages (262-265)

Title : Analgesia Effects of Detomidine HCl When Administered into the Distal Interphalangeal Joint in Horses with Experimental Solar Pain. ( Analgesia Effects of Detomidine HCl When Administered Into the Distal Interphalangeal Joint in Horses With Experimental Solar Pain )

Authors: Kamran Sardari , Hossein Kazemi Mehrjerdi , Mehrdad Mohri , Rene VanWeeren ,

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Stimulation of the sympathetic nervous system, act- ing through the release of noradrenaline, influences the nociceptor activity that develops after tissue surgery. The alpha-2 adrenergic agonist detomidine produces analge- sia through a central mechanism but also inhibits nora- drenaline release at terminal nerve fiber endings. Detomidine may induce analgesia when administered at peripheral sites (eg, at the joint cavity or around the nerves). An experimental lameness was induced in the toe region of the left forelimb in 6 adult horses to test the anal- gesic effects of detomidine at a peripheral site. Lameness was induced by creating pressure on the dorsal margin of the sole with the help of set-screws that were screwed into a nut, then welded to the inside of each branch of the shoe. Gaits were recorded on videotape before and after application of the screws and after application of either detomidine HCl or saline into the distal interphalangeal (DIP) joint. The gaits were evaluated independently by 2 blinded clinicians and scored. Lameness scores were high after application of the screws and remained high after the administration of saline but decreased signifi- cantly (P < .05) after administration of detomidine HCl. It was concluded that detomidine HCl produces analgesia by intrasynovial administration in horses in a similar fashion as local anaesthetic agents and thus may be a good alternative for these.

Keywords

Detomidine; Distal interphalangeal joint; Lameness; Local
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@article{paperid:101905,
author = {Sardari, Kamran and Kazemi Mehrjerdi, Hossein and Mohri, Mehrdad and Rene VanWeeren},
title = {Analgesia Effects of Detomidine HCl When Administered into the Distal Interphalangeal Joint in Horses with Experimental Solar Pain.},
journal = {Journal of Equine Veterinary Science},
year = {2005},
volume = {25},
number = {6},
month = {February},
issn = {0737-0806},
pages = {262--265},
numpages = {3},
keywords = {Detomidine; Distal interphalangeal joint; Lameness; Local analgesia},
}

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%0 Journal Article
%T Analgesia Effects of Detomidine HCl When Administered into the Distal Interphalangeal Joint in Horses with Experimental Solar Pain.
%A Sardari, Kamran
%A Kazemi Mehrjerdi, Hossein
%A Mohri, Mehrdad
%A Rene VanWeeren
%J Journal of Equine Veterinary Science
%@ 0737-0806
%D 2005

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