Title : ( Thiazolo[4,5- d ]pyrimidines: synthesis and antibacterial evaluation )
Authors: Mohammad Rahimizadeh , Mehdi Bakavoli , Ali Shiri , , Parvaneh Pordeli , Fatemeh Oroojalian ,
Full TextAbstract
The reaction of 4-amino-5-bromo-2-chloro-6-methylpyrimidine ( 1 ) with carbon disulfi de in the presence of KOH in DMF quantitatively gave 5-chloro-7-methylthiazolo[4,5- d ] pyrimidine-2 (3 H )-thione ( 2 ) which was then alkylated at the sulfur atom with various alkyl halides in the presence of Et 3 N in acetonitrile to give alkylthio derivatives 3 . The substitution of the chlorine atom in 3 with morpholine was also investigated. The synthesized compounds were subjected to antibacterial evaluations.
Keywords
, antibacterial evaluation; heterocyclization;thiazolo[4, 5-d]pyrimidine
@article{paperid:1022607,
author = {Rahimizadeh, Mohammad and Bakavoli, Mehdi and Shiri, Ali and , and Pordeli, Parvaneh and Fatemeh Oroojalian},
title = {Thiazolo[4,5- d ]pyrimidines: synthesis and antibacterial evaluation},
journal = {Heterocyclic Communications},
year = {2011},
volume = {17},
number = {1},
month = {January},
issn = {0793-0283},
pages = {43--47},
numpages = {4},
keywords = {antibacterial evaluation; heterocyclization;thiazolo[4;5-d]pyrimidine},
}
%0 Journal Article
%T Thiazolo[4,5- d ]pyrimidines: synthesis and antibacterial evaluation
%A Rahimizadeh, Mohammad
%A Bakavoli, Mehdi
%A Shiri, Ali
%A ,
%A Pordeli, Parvaneh
%A Fatemeh Oroojalian
%J Heterocyclic Communications
%@ 0793-0283
%D 2011
