Comparative Clinical Pathology, ( ISI ), Volume (22), No (6), Year (2013-11) , Pages (1043-1049)

Title : ( Oxidant/antioxidant balance and trace elements status in sheep with liver cystic echinococcosis )

Authors: Mohammad Heidarpour , Mehrdad Mohri , Hassan Borji , elham moghaddas ,

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This study aimed to determine the trace elements and oxidative stress markers as contributory factors causing liver injury and erythrocyte destruction in sheep with liver cystic echinococcosis. In comparison to healthy control, the index of serum lipid peroxidation assessed by the malonyldialdehyde (MDA) level was significantly (P<0.001) higher and the concentrations of serum total antioxidant status (TAS) and trace elements (zinc, copper, and iron) were significantly (P<0.001) lower in sheep with liver cystic echinoccocosis. No significant differences were observed for erythrocyte glutathione peroxidase (GPx) and superoxide dismutase activities between infected and healthy groups. In infected sheep, a significant positive correlation of MDA with aspartate transaminase (AST) (r00.636, P0 0.000) and erythrocyte GPx (r00.373, P00.043) was observed. By contrast, serum MDA concentration was negatively correlated with the values of TAS (r0−0.559, P00.001) and packed cell volume (PCV; r0−0.473, P00.008). On the other hand, there was a significant negative correlation between serum TAS concentration and the levels of AST (r0 −0.433, P00.017) and MDA (r0−0.559, P00.001). By contrast, serum TAS was positively correlated with the value of PCV (r00.728, P00.000). From the present study, it was concluded that cystic echinococcosis in sheep is associated with oxidative stress. The resulting oxidative stress seems to have a role in the injury of hepatocytes and erythrocytes

Keywords

Oxidative stress . Trace elements . Sheep
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@article{paperid:1028563,
author = {Heidarpour, Mohammad and Mohri, Mehrdad and Borji, Hassan and Moghaddas, Elham},
title = {Oxidant/antioxidant balance and trace elements status in sheep with liver cystic echinococcosis},
journal = {Comparative Clinical Pathology},
year = {2013},
volume = {22},
number = {6},
month = {November},
issn = {1618-5641},
pages = {1043--1049},
numpages = {6},
keywords = {Oxidative stress . Trace elements . Sheep . Echinococcosis},
}

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%0 Journal Article
%T Oxidant/antioxidant balance and trace elements status in sheep with liver cystic echinococcosis
%A Heidarpour, Mohammad
%A Mohri, Mehrdad
%A Borji, Hassan
%A Moghaddas, Elham
%J Comparative Clinical Pathology
%@ 1618-5641
%D 2013

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