Title : ( The cytotoxic activities of 7-isopentenyloxycoumarin on 5637 cells via induction of apoptosis and cell cycle arrest in G2/M stage )
Authors: fereshteh haghighi , Maryam Moghaddam Matin , Ahmad Reza Bahrami , Mehrdad Iranshahi , Fatemeh Behnam Rassouli , Azadeh Haghighitalab ,
Full TextAbstract
Background: Bladder cancer is the second common malignancy of genitourinary tract, and transitional cell carcinomas (TCCs) account for 90% of all bladder cancers. Due to acquired resistance of TCC cells to a wide range of chemotherapeutic agents, there is always a need for search on new compounds for treatment of these cancers. Coumarins represent a group of natural compounds, which some of them have exerted valuable anti-tumor activities. The current study was designed to evaluate anti-tumor properties and mechanism of action of 7-isopentenyloxycoumarin, a prenyloxycoumarin, on 5637 cells (a TCC cell line).
Keywords
, Bladder cancer, Cytotoxicity, 7-isopentenyloxycoumarin, Apoptosis, Cell cycle
@article{paperid:1039873,
author = {Haghighi, Fereshteh and Moghaddam Matin, Maryam and Bahrami, Ahmad Reza and Mehrdad Iranshahi and Behnam Rassouli, Fatemeh and Haghighitalab, Azadeh},
title = {The cytotoxic activities of 7-isopentenyloxycoumarin on 5637 cells via induction of apoptosis and cell cycle arrest in G2/M stage},
journal = {DARU Journal of Pharmaceutical Sciences},
year = {2014},
volume = {22},
number = {1},
month = {January},
issn = {1560-8115},
pages = {1--10},
numpages = {9},
keywords = {Bladder cancer; Cytotoxicity; 7-isopentenyloxycoumarin; Apoptosis; Cell cycle},
}
%0 Journal Article
%T The cytotoxic activities of 7-isopentenyloxycoumarin on 5637 cells via induction of apoptosis and cell cycle arrest in G2/M stage
%A Haghighi, Fereshteh
%A Moghaddam Matin, Maryam
%A Bahrami, Ahmad Reza
%A Mehrdad Iranshahi
%A Behnam Rassouli, Fatemeh
%A Haghighitalab, Azadeh
%J DARU Journal of Pharmaceutical Sciences
%@ 1560-8115
%D 2014
