Title : ( Mechanisms of hepatitis B virus-induced hepatocellular carcinoma )
Authors: sohrab boozarpour , Mansour Mashreghi , Mahdi Mirahmadi ,
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Abstract
Hepatocellular carcinoma (HCC) is one of the most common fatal cancers in the world and hepatitis B virus (HBV) is one of the major causes of HCC. The pathogenesis of HBVrelated HCC, however, has not been fully examined. HBV induces HCC by genome integration and expression of trans-activating factors derived from the HBV genome. Evidence suggests that the HBV X protein (HBx) plays an essential role in the pathogenesis of HCC. We have reviewed the mechanism of hepatocarcinogenesis at the molecular level with a particular emphasis on the role of X protein
Keywords
, HBV, HBV X protein, hepatocellular carcinoma
@article{paperid:1040155,
author = {Boozarpour, Sohrab and Mashreghi, Mansour and Mahdi Mirahmadi},
title = {Mechanisms of hepatitis B virus-induced hepatocellular carcinoma},
journal = {Reviews in Medical Microbiology},
year = {2014},
volume = {25},
number = {1},
month = {January},
issn = {0954-139X},
pages = {20--25},
numpages = {5},
keywords = {HBV; HBV X protein; hepatocellular carcinoma},
}
%0 Journal Article
%T Mechanisms of hepatitis B virus-induced hepatocellular carcinoma
%A Boozarpour, Sohrab
%A Mashreghi, Mansour
%A Mahdi Mirahmadi
%J Reviews in Medical Microbiology
%@ 0954-139X
%D 2014
