tDue to the development of resistance to antimicrobial drugs of several multi-drug resistancepathogens, the discovery of new active agents has become a major public health concern.The purpose of this study was to evaluate the antifungal activity of hydroalcoholic extract ofCitrullus colocynthis fruits against different Candida and Aspergillus strains. Anti-Candida andanti-Aspergillus effects of the extract were determined by disk diffusion and broth macrodilu-tion methods. The study revealed that all tested fungal strains were sensitive to the extract.The growth inhibition value of the extract showed high antifungal activity against Aspergillusfumigatus and Aspergillus niger and a lesser effect against Candida guilliermondii and Candidakreusei. The minimal inhibitory concentration (MIC) and minimum fungicidal concentration(MFC) values ranged from 1.56 to 12.5 mg/ml and 3.125 to 25 mg/ml, respectively. The resultsobtained in the present study suggest that C. colocynthis may be a valuable plant source ofmedicinally useful active compounds that can be used for the treatment of some fungalinfections.

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