Title : ( An Eco-friendly Three Component Manifold for the Synthesis of -Aminophosphonates under Catalyst and Solvent-free Conditions, X-ray Characterization and Their Evaluation as Anticancer Agents )
Authors: mehdi mirzaei , Hossein Eshghi , Mohammad Rahimizadeh , Mehdi Bakavoli , Maryam Moghaddam Matin , minoo hoseiny mehr , Hadi Amiri Rudbari , Giuseppe Bruno ,
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Abstract
Aseries of a-aminophosphonates were synthesized through one-pot condensation of aryl aldehydes, aryl amines and diethyl phosphite in the absence of any catalyst and organic solvents. All the synthesized a-aminophosphonates were characterized by spectral and elemental analysis and in the case of compound 4j by X-ray crystallography. Some of these new a-aminophosphonate derivatives were found to have cytotoxic activity on the cancer cell line DU145 in vitro by the MTT method.
Keywords
, Anticancer activity; Catalyst free; Solvent free; a, Aminophosphonates; X, ray analysis.
@article{paperid:1053287,
author = {Mirzaei, Mehdi and Eshghi, Hossein and Rahimizadeh, Mohammad and Bakavoli, Mehdi and Moghaddam Matin, Maryam and Hoseiny Mehr, Minoo and Hadi Amiri Rudbari and Giuseppe Bruno},
title = {An Eco-friendly Three Component Manifold for the Synthesis of -Aminophosphonates under Catalyst and Solvent-free Conditions, X-ray Characterization and Their Evaluation as Anticancer Agents},
journal = {Journal of the Chinese Chemical Society},
year = {2015},
volume = {62},
number = {12},
month = {November},
issn = {0009-4536},
pages = {1087--1096},
numpages = {9},
keywords = {Anticancer activity; Catalyst free; Solvent free; a-Aminophosphonates; X-ray analysis.},
}
%0 Journal Article
%T An Eco-friendly Three Component Manifold for the Synthesis of -Aminophosphonates under Catalyst and Solvent-free Conditions, X-ray Characterization and Their Evaluation as Anticancer Agents
%A Mirzaei, Mehdi
%A Eshghi, Hossein
%A Rahimizadeh, Mohammad
%A Bakavoli, Mehdi
%A Moghaddam Matin, Maryam
%A Hoseiny Mehr, Minoo
%A Hadi Amiri Rudbari
%A Giuseppe Bruno
%J Journal of the Chinese Chemical Society
%@ 0009-4536
%D 2015
