Title : ( Synthesis of 5,5-(ethane-1,2-diyl) bis (3-((5-bromo-6-methyl-2tertiaryaminopyrimidin-4-yl) thio)-4H-1,2,4-triazol-4-amines) and Their Novel bis-cyclized Products, 1,2-bis (pyrimido [5,4e] [1,2,4] triazolo [3,4-b] [1,3,4] thiadiazin-3-yl) ethane, as Potential Inhibitors of 15-Lipoxygenase )
Authors: tayebe asghari shirghan , Mehdi Bakavoli , Hossein Eshghi , satar saberi , ,
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Abstract
Several new derivatives of 5,5′-(ethane-1,2-diyl)bis(3-((5-bromo-6-methyl-2-tertiaryamino pyrimidin-4yl)thio)-4H-1,2,4-triazol-4-amine)(4a–f) and their novel cyclized products, 1,2-bis(pyrimido[5,4-e][1,2,4] triazolo[3,4-b][1,3,4]thiadiazin-3-yl)ethane (5a–f) were synthesized and evaluated as potential inhibitors of 15-lipoxygenase (15-LO). The compounds 4c (1-methylpiperazine) and 4d (1-ethylpiperazine) showed the best IC50 of 15-LO inhibition (IC50= 4.15 and 2.9 μM, respectively).
Keywords
, 5, 5′-(ethane-1, 2-diyl)bis(3-((5-bromo-6-methyl-2tertiaryaminopyrimidin-4-yl)thio)-4H-1, 2, 4-triazol-4-amines) 1, 2-bis(pyrimido[5, 4e][1, 2, 4] triazolo[3, 4-b][1, 3, 4]thiadiazin-3-yl)ethane, 15-Lipoxygenase
@article{paperid:1053863,
author = {Asghari Shirghan, Tayebe and Bakavoli, Mehdi and Eshghi, Hossein and Saberi, Satar and , },
title = {Synthesis of 5,5-(ethane-1,2-diyl) bis (3-((5-bromo-6-methyl-2tertiaryaminopyrimidin-4-yl) thio)-4H-1,2,4-triazol-4-amines) and Their Novel bis-cyclized Products, 1,2-bis (pyrimido [5,4e] [1,2,4] triazolo [3,4-b] [1,3,4] thiadiazin-3-yl) ethane, as Potential Inhibitors of 15-Lipoxygenase},
journal = {Journal of Heterocyclic Chemistry},
year = {2016},
volume = {53},
number = {2},
month = {March},
issn = {0022-152X},
pages = {403--407},
numpages = {4},
keywords = {5;5′-(ethane-1;2-diyl)bis(3-((5-bromo-6-methyl-2tertiaryaminopyrimidin-4-yl)thio)-4H-1;2;4-triazol-4-amines) 1;2-bis(pyrimido[5;4e][1;2;4] triazolo[3;4-b][1;3;4]thiadiazin-3-yl)ethane;
15-Lipoxygenase},
}
%0 Journal Article
%T Synthesis of 5,5-(ethane-1,2-diyl) bis (3-((5-bromo-6-methyl-2tertiaryaminopyrimidin-4-yl) thio)-4H-1,2,4-triazol-4-amines) and Their Novel bis-cyclized Products, 1,2-bis (pyrimido [5,4e] [1,2,4] triazolo [3,4-b] [1,3,4] thiadiazin-3-yl) ethane, as Potential Inhibitors of 15-Lipoxygenase
%A Asghari Shirghan, Tayebe
%A Bakavoli, Mehdi
%A Eshghi, Hossein
%A Saberi, Satar
%A ,
%J Journal of Heterocyclic Chemistry
%@ 0022-152X
%D 2016
