Experimental Gerontology, Volume (67), No (1), Year (2015-4) , Pages (9-14)

Title : ( Exercise training increases anabolic and attenuates catabolic and apoptotic processes in aged skeletal muscle of male rats )

Authors: Mohammad Mosaferi Ziaaldini , Erika Koltai , Zsolt Csende , Sataro Goto , Istvan Boldogh , AlbertW. Taylor , Zsolt Radak ,

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Aging results in significant loss of mass and function of the skeletal muscle, which negatively impacts the quality of life. In this study we investigated whether aerobic exercise training has the potential to alter anabolic and catabolic pathways in the skeletal muscle. Five and twenty eight month old rats were used in the study. Aging resulted in decreased levels of follistatin/mTOR/Akt/Erk activation and increased myostatin/Murf1/2, proteasome subunits, and protein ubiquitination levels. In addition, TNF-α, reactive oxygen species (ROS), p53, and Bax levels were increased while Bcl-2 levels were decreased in the skeletal muscle of aged rats. Six weeks of exercise training at 60% of VO2max reversed the age-associated activation of catabolic and apoptotic pathways and increased anabolic signaling. The results suggest that the age-associated loss of muscle mass and cachexia could be due to the orchestrated down-regulation of anabolic and up-regulation of catabolic and pro-apoptotic processes. These metabolic changes can be attenuated by exercise training.

Keywords

Aging; Skeletal muscle; Reactive oxygen species; Myostatin;
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@article{paperid:1056544,
author = {Mosaferi Ziaaldini, Mohammad and Erika Koltai and Zsolt Csende and Sataro Goto and Istvan Boldogh and AlbertW. Taylor and Zsolt Radak},
title = {Exercise training increases anabolic and attenuates catabolic and apoptotic processes in aged skeletal muscle of male rats},
journal = {Experimental Gerontology},
year = {2015},
volume = {67},
number = {1},
month = {April},
issn = {0531-5565},
pages = {9--14},
numpages = {5},
keywords = {Aging; Skeletal muscle; Reactive oxygen species; Myostatin; Follistatin},
}

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%0 Journal Article
%T Exercise training increases anabolic and attenuates catabolic and apoptotic processes in aged skeletal muscle of male rats
%A Mosaferi Ziaaldini, Mohammad
%A Erika Koltai
%A Zsolt Csende
%A Sataro Goto
%A Istvan Boldogh
%A AlbertW. Taylor
%A Zsolt Radak
%J Experimental Gerontology
%@ 0531-5565
%D 2015

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