Cancers, as a major source of the mortality in the world, are causing by the various environmental and internal factors. So, there are various commercial or in developing approaches for diagnosis, prevention and treatment of these diseases in the global health network. In this regard, immunotoxin development is a promising and new method for targeting malignancies cells. However, access to such medication requires a thorough understanding of the cell surface specific antigens of the malignancies cell as well as associated ligands, which is considered in this study for ovarian cancer. In this regard, comparative analysis on the in-silico expression of the cell surface specific antigens of the ovarian cancer led to reveal the high and specific expression of the MAGE4 for this type of cancer. Moreover, our survey for detection the corresponding ligands of the MAGE4, white string programs, led to reveal the PSMD10, TRIM69, UQCRB, CTAG1B, EID3, NSMCE4A, NSMCE1, UBC, MSX1 and MSX2 as specific ligands with suitable binding affinity to the antigen. Nonetheless, ligands validation based on the length, affinity to the antigen, post-translation modification as well as topology of the ligands with corresponding molecule to the cells showed that the TRIM69 is an ideal candidate for immunotoxin development with ability to targeting MAGE4.

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