Title : ( Light and electron microscopic investigation of semelil (angiparstm) on therapeutic process after chronic myocardial infarction in rabbit )
Authors: Abouzar Talakoub , Abolghasem Nabipour , MOHSEN MALEKI , Majid Asadi - Shekaari , Mostafa Latifpour , Hamid Reza Khorramkhorshid ,
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Abstract
One of the main therapeutic intentions of modern cardiology is to contrive strategies aimed at decreasing myocardial necrosis and improving cardiac healing following myocardial infarction (MI). This investigation was contrived to study the protective effects of Semelil (ANGIPARS™), a native herbal medicine, on MI in the rabbit model. In this experimental study, Twenty New Zealand white rabbits were utilized. Rabbits were allocated to equal groups: control plus vehicle; sham plus vehicle; ischemia plus vehicle; Semelil 10 mg/kg, respectively. MI was created by the complete closure of Left Anterior Descending Coronary Artery (LADC). The animals were treated with Semelil 10 mg/kg daily for 14 days. Electrophysiological, Biochemical, histological and ultrastructural studies were used for detecting protective effects of Semelil. Based on our data, Semelil ameliorated the electrocardiogram (ECG) pattern. Besides, treatment with Semelil improved Creatine Kinase, creating kinase isoenzyme and Lactate dehydrogenase levels comparing to the ischemia group. Morphological data showed that Semelil could protect cardiomyocytes against myocardial infarction insults. The results demonstrate that Semelil may have protective effects against ischemic damages induced by LADC obstruction in male rabbits due to its anti-inflammatory and antioxidant properties
Keywords
, Myocardial infarction, Mitochondria, Semelil, necrosis, Rabbits
@article{paperid:1061923,
author = {Talakoub, Abouzar and Nabipour, Abolghasem and MALEKI, MOHSEN and Majid Asadi - Shekaari and Mostafa Latifpour and Hamid Reza Khorramkhorshid},
title = {Light and electron microscopic investigation of semelil (angiparstm) on therapeutic process after chronic myocardial infarction in rabbit},
journal = {IIOAB Journal},
year = {2017},
volume = {8},
number = {1},
month = {January},
issn = {0976-3104},
pages = {54--60},
numpages = {6},
keywords = {Myocardial infarction; Mitochondria; Semelil; necrosis; Rabbits},
}
%0 Journal Article
%T Light and electron microscopic investigation of semelil (angiparstm) on therapeutic process after chronic myocardial infarction in rabbit
%A Talakoub, Abouzar
%A Nabipour, Abolghasem
%A MALEKI, MOHSEN
%A Majid Asadi - Shekaari
%A Mostafa Latifpour
%A Hamid Reza Khorramkhorshid
%J IIOAB Journal
%@ 0976-3104
%D 2017
