Background: Diazinon (DZN), an organophosphate pesticide, is commonly used for pest control in the agricultural, which could engender a variety of negative effects in non-target species including humans and animals. The objective of the present study was to evaluate the ameliorative properties of captopril (CAP) as a thiol containing ACEi (angiotensin converting enzyme inhibitor) against the DZN-induced oxidative stress. Methods: Twenty-eight male Wistar rats were divided randomly into four groups. All the rats were treated orally via gavage once a day for 7 weeks: control (corn oil), CAP (10 mg/kg), DZN (10 mg/kg) and CAP+DZN combination (as mentioned above). Oxidative stress indices in blood serum, liver and kidney homogenate [malondialdehyde (MDA), total thiol groups and total antioxidant capacity (TAC)], and in erythrocyte hemolysis [superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX)] were evaluated. Statistical analysis was performed using GraphPad Prism software 6.0. (GraphPad, San Diego, CA, USA) by one-way analysis of variance (ANOVA), followed by Tukey post hoc analysis. Results: The results revealed that the level of MDA and the activity of SOD increased significantly in the DZN group compared with the control group. Treatment with CAP in DZN-exposed group led to a significant decrease (p<0.05) in MDA concentration and SOD activity. The total thiol groups decreased in DZN group and elevated again by CAP treatment. Conclusion: The results of the present study demonstrated that co-administration of CAP with DZN can attenuate lipid peroxidation and enzyme changes caused by DZN.

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