In this study, a fluid-structure interaction -FSI- simulation of the blood flow in the femoral artery with a small occlusion is 16 presented. For a more accurate simulation of the real conditions, computerized tomography -CT- scan was used to obtain a 3-D 17 model of leg blood vessels, while the vessel was modeled as an isotropic elastic wall. By assuming a heartbeat period of 0.5 s, the 18 inlet condition was considered as a time-dependent pulse using a non-Newtonian flow model. Blood flow was assumed nonlinear 19 and incompressible, and Carreau model was used for blood rheological model. 20 By considering unstable blood flow at the inlet, the involved hemodynamic parameters are velocity profile, vortices shapes, 21 pressure drop, and streamlines. Furthermore, to determine the relationship between flow geometry and the vascular wall, wall 22 shear stress -WSS- was calculated. 23 By taking the real geometry of the vessel and fluidity of blood into account, comparison of computational results indicated a 24 significant difference in velocity distribution and shear stress depending on whether the fluid-structure interaction is considered 25 Newtonian or non-Newtonian. The results showed that employing Newtonian models for the blood flow does not lead to 26 promising results at occluded areas and beyond them.

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