Objective It has been shown that several environmental and physiological factors can affect on the serum levels of calcium and phosphate. The objective of the present study was explored the relationship between serum calcium and phosphate levels with anthropometric and hematological markers. Methods 908 subjects were recruited from the Mashhad stroke and heart atherosclerosis disorder -MASHHAD- program. Anthropometric parameters, liver/kidney function tests -e.g., Urea nitrogen, creatinine, urea and uric acid, creatinine, AST, ALT- were determined in all participants. Serum concentrations of calcium and phosphate were measured using Autoanalyzer BT3000P -Pars Azmoon kit, Tehran, Iran-. SPSS software was used for statistical analyses. Results We observed that obese subjects had a lower level of serum calcium -p˂0.05-. Moreover, a relationship was detected between serum phosphate level and different menopausal status -p˂0.05-. Serum calcium and phosphate did not change by increasing age in the population. Additionally, there was a correlation between lymphocyte count with serum phosphate level -p˂0.05-. No statistically different were detected for the levels of calcium/phosphate with respect to smoking status, physical activity, lipid profile, liver and renal function markers. Conclusion We found an association between serum calcium and BMI as well as with serum phosphate and menopausal status.

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