Background and objective: Several diseases interfere with spermatogenesis including diabetes mellitus (DM), coronary heart disease, and chronic liver diseases. Diabetes mellitus has adverse effects on the fertility of diabetic patients; for instance, it causes abnormal spermatogenesis with sperm deformities and decreases testis weight. The purpose of this study was to evaluate the effects of ellagic acid on testis weight following isoproterenol-induced myocardial infarction in diabetic male rats. Materials and methods: Male Wistar rats (295±25 g) were randomly divided into 5 experimental groups (n=10, each). The first group was the non-diabetic control. Diabetes mellitus was induced in all other groups using streptozotocin (55 mg/kg, i.p.). Group II the diabetic control. Group III was gavaged with ellagic acid (50 mg/kg) for 21 days. Myocardial infarction was induced in groups IV and V via injection of isoproterenol (100 mg/kg, i.p.) for two consecutive days. However, group V was further treated with ellagic acid (50 mg/kg) for 21 days. On day 21, testis weights were recorded in all rats. Results: Streptozotocin caused significant reductions in testis weights in all diabetic groups (p<0.05). Co-administration of ellagic acid significantly increased this parameter in both infarcted and non-infarcted groups (p<0.05). Conclusion: This study suggests beneficial effects for ellagic acid in improving testis weights in diabetic male rats. This effect seems to be independent of myocardial infarction.

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