This study aims to fabricate a three-dimensional polymethyl methacrylate (PMMA) scaffold and investigating its structural and mechanical properties. To fabricate scaffold with a 3D porous interconnected structure, a laser cuts the PMMA sheets into the desired pattern and then these layers were stacked and bonded on each other. Mechanical properties of the fabricated scaffolds were investigated both numerically and experimentally. In order to elevate the bioactivity property of the scaffolds, a layer of chitosan/bioglass composite was coated on their surfaces. Moreover, the cell viability, cell proliferation and morphology of pores were studied. Results demonstrated that this method has the advantages of interconnectivity, controllability of pore size, porosity, and accurate mechanical properties. Also, a good correspondence between the results of compressive strength tests and finite element analysis (FEA) shows that the proposed model can predict precisely mechanical properties of the scaffold. Furthermore, chitosan/bioglass composite coating, improves extremely the number of cell proliferation and bioactivity of the scaffold.

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