Title : ( Improvement of the Wound-Healing Process by Curcumin-Loaded Chitosan/Collagen Blend Electrospun Nanofibers: In Vitro and In Vivo Studies )
Authors: Nafiseh Jirofti , mohadese golandi , Jebrail Movaffagh , Farajollah Shahriari Ahmadi , Fatemeh Kalalinia ,
Full TextAbstract
Chronic wounds have become a major health problem worldwide. Curcumin (Cur), with strong anti-inflammatory and anti-infective properties, is introduced as a unique molecule for wound dressing applications. In the present study, Cur-loaded chitosan/poly(ethylene oxide)/collagen (Cho/PEO/Col) nanofibers were developed for wound dressing applications by the blend−electrospinning process. Structural, mechanical, and biological properties of nanofibers were evaluated using SEM, FTIR, tensile testing, in vitro release study, Alamar blue cytotoxicity assay, and in vivo study in a rat model. According to the results, Cur was successfully released up to 3 days without any significant cytotoxicity of the above hybrid to human dermal fibroblasts. In vivo studies on full-thickness wounds in the rat model indicated significant improvement in the mean wound area closure by applying Cur-loaded Cho/PEO/Col nanofibers. The electrospun Cho/PEO/Col nanofibers loaded with Cur could be considered as a promising type of wound dressing in the wound wound healing process.
Keywords
, wound dressing, curcumin, collagen, chitosan, electrospun nanofibers
@article{paperid:1086560,
author = {Nafiseh Jirofti and Golandi, Mohadese and Jebrail Movaffagh and Shahriari Ahmadi, Farajollah and Fatemeh Kalalinia},
title = {Improvement of the Wound-Healing Process by Curcumin-Loaded Chitosan/Collagen Blend Electrospun Nanofibers: In Vitro and In Vivo Studies},
journal = {ACS Biomaterials Science and Engineering},
year = {2021},
volume = {7},
number = {8},
month = {August},
issn = {2373-9878},
pages = {3886--3897},
numpages = {11},
keywords = {wound dressing; curcumin; collagen; chitosan; electrospun nanofibers},
}
%0 Journal Article
%T Improvement of the Wound-Healing Process by Curcumin-Loaded Chitosan/Collagen Blend Electrospun Nanofibers: In Vitro and In Vivo Studies
%A Nafiseh Jirofti
%A Golandi, Mohadese
%A Jebrail Movaffagh
%A Shahriari Ahmadi, Farajollah
%A Fatemeh Kalalinia
%J ACS Biomaterials Science and Engineering
%@ 2373-9878
%D 2021
