The combination of nano fluid and changing cross ‑section mini‑channel heat sink effects have become a remarkable choice for the use of thermal devices such as miniature electronic devices to be effectively cooled. In this paper, the comparison of three dimensional straight and wavy channel configuration with using different types nano fluids are numerically investigated. The effects of wave amplitude and A particular type of volume fraction of (Copper Oxide CuO, Dimond Al 2 O 3 , Iron Oxide Fe 3 O 4 , Titanium Oxide TiO 2 and Silver Ag‑nano fluids are offered. Three amplitudes of waves (0.15 mm, 0.2 mm and 0.25 mm) and Reynold’s number from 200 to 1000 and concentration volume varieties from 0 to 0.075 are used. The effect on thermal resistance, pressures drop, factor of friction of the mini channel is displayed. It is observed that the mini‑channel sink’s heat transfer efficiency is greatly enhanced compared to the straight channel in an event of adding distilled water as accoolant. The results indicate that nano fluid and wavy mini‑channel can boost the heat sink’s hydrothermal efficiency and Ag ‑ water nano fluid in term of heat transfer, it outperforms other nanofluids an enhancement in the Nusselt number reached to 54% at concentration volume 0.075.

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