Purpose: The present study aimed to examine the effect of physical activity on the quality of life and mental health of Ferdowsi University students whose field of study was not physical education during the COVID-19 Pandemic. Method: The method of study was descriptive and correlational. The statistical population of this present study consisted of all male and female students of Ferdowsi University whose field of study was not physical education and they had chosen physical education 1 and Sports 1. Data were collected from 375 Ferdowsi University students whose field of study was not physical education and they were selected randomly. Data collection was done through Physical Activity Questionnaire by Wickramarachchi et al. (2021), Mental Health Questionnaire by Proto. & Quintana-Domeque (2021), and Quality of Life Questionnaire by Epifanio et al. (2021). The validity and reliability of the questionnaires were also confirmed and Structural Equation Modeling (SEM) was used to analyze the data.Findings: The results showed a direct and statistically significant effect of physical activities on the quality of life, which was obtained at 0.958. 

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