In the present study, synthesis of a variety of 5-bromo-4-methyl-2-substituted pyrimidines endowed with pyrazolyl sub- stituent appended in C4 position (7a-f) is described. These products are generated via treatment of 5-bromo-4-hydrazin- eyl-6-methyl-2-substituted pyrimidines (6a–f) and vinamidinum salt of (E)-N-(3-(dimethylamino)-2-phenylallylidene)-N- methylmethanaminium perchlorate (5) in good to excellent yields. The inhibitory and hydrogen-atom donating abilities of the synthesized products (7a-f) were assessed against nine pathogens including six bacterial strains (both Gram-negative and Gram-positive), three fungal strains and DPPH free radicals. Notable antioxidant properties were not observed with the products. IC50 values were in the range of 107.49–929.16 μg ml−1. The inhibition zone diameters of products at 10 mg ml−1 concentrations were recorded in the range of 10.51–18.44 mm via disk di usion method. 5-Bromo-4-methyl-6-pyra- zolylpyrimidine (7e) containing 2-(4-methylpiperazin) substituent showed better antioxidant and antimicrobial e ects than other products. It was e ective on all the tested microbial strains except Staphylococcus epidermidis. All the synthesized pyrazolyl pyrimidines, especially (7e) can be used to disinfect the environment and treat infectious diseases.

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