The current status of water resources in the U.S. Central High Plains necessitates adopting water conservation practices to move toward a sustainable agricultural economy. Identifying proper irrigation scheduling techniques is a conservative practice to maintain the sustainability of the agricultural systems. However, conducting field experiments is time and money consuming. Thus, the utilization of crop models, such as AquaCrop, could be a convenient alternative to field experiments. The FAO AquaCrop model was calibrated and validated for simulating forage sorghum yield response to various deficit irrigation conditions in a semi-arid region. Afterwards, the model was used to investigate the efficiency of the pre-season and in-season irrigation scheduling scenarios. In this study, the soil water status at the planting time was considered as the indicator of the pre-season irrigation level. Therefore, the pre-season irrigation scenarios were arranged as the replenishment of soil water deficiency at the time of planting at up to 30, 50, and 100% of the soil’s total available water for the first 60 cm of soil depth and the same replenishment levels for the entire crop root zone (150 cm soil depth). Then, AquaCrop long-term (37 years) simulations of forage sorghum biomass and irrigation water use efficiency reactions to three levels of maximum allowable depletion (MAD) (40, 55, and 70%) were compared to three fixed irrigation interval (4, 6, and 10 days) scenarios by considering six pre-season irrigation conditions (36 scenarios). The scenarios analysis found the 10-day irrigation interval and the MAD levels of 55% and 70% to be the most efficient irrigation scheduling strategies if combined with pre-season irrigation that brought the crop root zone (0–150 cm soil depth) to field capacity. Moreover, the 40% MAD application was the least efficient strategy. This study’s outputs can be a baseline for establishing forage sorghum irrigation scheduling in the U.S. Central High Plains. However, exploring the interactions of irrigation scheduling strategies with other irrigation and agronomic practices, such as salinity management and fertilizer application, is highly recommended

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