Carbohydrate Polymer Technologies and Applications, Volume (7), No (7), Year (2024-6) , Pages (100418-100432)

Title : ( Chitosan/Nanohydroxyapatite/Hydroxyethyl-cellulose-based printable formulations for local alendronate drug delivery in osteoporosis treatment )

Authors: Simindokht Afra , Marcus Koch , Joanna Zur-Pinska , Maryam Dolatshahi , Ahmad Reza Bahrami , Julien Es Sayed , Ali Moradi , Maryam Moghaddam Matin , Malgorzata Katarzyna Wlodarczyk-Biegun ,

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Abstract

Osteoporosis is a silent bone disease and a growing health issue. Despite recent progress in diagnosis and treatment, effective therapeutic strategies are still needed. One of the possible solutions is the implantation of engineered drug-releasing scaffolds at the disease site. To boost this approach further, we aimed to develop printable materials (the inks) for the construction of patient-specific 3D scaffolds with drug-release capability. The inks were composed of chitosan – a natural osteoinductive polysaccharide, nanohydroxyapatite – a natural bone matrix ingredient improving mechanical properties, sodium alendronate – a bioactive drug, and hydroxyethyl-cellulose – a filler improving the printability. Printed scaffolds were crosslinked with citric acid or KOH. After coating with collagen and gelatin, they demonstrated biocompatibility with the adipose-derived mesenchymal stem cells and MG-63 cell line. They also showed a sustained release of alendronate for 50 days, causing a significant reduction in the expression of Cathepsin K, an osteoclast-specific gene marker, which indicates the osteoclast-inhibiting capacity of the coated scaffolds. This work demonstrates the potential of developed printable materials to find applications as cell and drug carriers for the treatment of osteoporosis.

Keywords

Chitosan 3D bioprinting Osteoporosis Alendronate Osteoclastogenesis
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@article{paperid:1097868,
author = {Afra, Simindokht and Marcus Koch and Joanna Zur-Pinska and Dolatshahi, Maryam and Bahrami, Ahmad Reza and Julien Es Sayed and Ali Moradi and Moghaddam Matin, Maryam and Malgorzata Katarzyna Wlodarczyk-Biegun},
title = {Chitosan/Nanohydroxyapatite/Hydroxyethyl-cellulose-based printable formulations for local alendronate drug delivery in osteoporosis treatment},
journal = {Carbohydrate Polymer Technologies and Applications},
year = {2024},
volume = {7},
number = {7},
month = {June},
issn = {2666-8939},
pages = {100418--100432},
numpages = {14},
keywords = {Chitosan 3D bioprinting Osteoporosis Alendronate Osteoclastogenesis},
}

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%0 Journal Article
%T Chitosan/Nanohydroxyapatite/Hydroxyethyl-cellulose-based printable formulations for local alendronate drug delivery in osteoporosis treatment
%A Afra, Simindokht
%A Marcus Koch
%A Joanna Zur-Pinska
%A Dolatshahi, Maryam
%A Bahrami, Ahmad Reza
%A Julien Es Sayed
%A Ali Moradi
%A Moghaddam Matin, Maryam
%A Malgorzata Katarzyna Wlodarczyk-Biegun
%J Carbohydrate Polymer Technologies and Applications
%@ 2666-8939
%D 2024

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