Herbal medications and phytochemicals are becoming more popular cancer treatments owing to their compat- ibility, safety, simplicity of manufacture, low cost, and few adverse effects. However, low absorption rates and bioavailability limit the medicinal potential of bioactive substances. This review examines phytosome-based nanotechnology as a unique way to improve phytochemical solubility, bioavailability, and anticancer activity. Drugs and plant-derived nutraceuticals, such as polyphenolic chemicals, are encapsulated in phytosomes. Phy- tosomes, a food-grade delivery method, enhance phytochemical bioavailability by improving their cellular ab- sorption and protecting them from breakdown in harsh biological environments. This approach also facilitates targeted drug delivery, reducing off-target effects and systemic toxicity, thereby making therapy safer and more effective. Phytosome-based nanocarriers have improved the treatment of triple-negative breast cancer, ovarian cancer, liver cancer, and melanoma using compounds like curcumin, quercetin, silibinin, sinigrin, mitomycin C, and luteolin. In conclusion, phytosome-based nanotechnology has the potential to enhance bioavailability and enable tailored drug administration, revolutionizing phytochemical anticancer therapy. Despite its promise, this technique faces challenges, including large-scale manufacturing, stability, and clinical validation. Nevertheless, with further investigation, phytosome technology could play a crucial role in the future of cancer therapeutics.

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