Title : ( Serum uric acid to high‐density lipoprotein ratio as a novel indicator of inflammation is correlated with the presence and severity of metabolic syndrome: A large‐scale study )
Authors: Rana Kolahi Ahari , Amin Mansoori , Toktam Sahranavard , Monireh Sadat Miri , Sara Feizi , Habibollah Esmaily , Majid Ghayour-Mobarhan ,
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Abstract
Introduction We investigated the association of serum uric acid to high-density lipoprotein ratio (UHR) with the presence and severity of metabolic syndrome (MetS) among MASHAD cohort participants. Methods In this cross-sectional study, according to International Diabetes Federation criteria, the cohort participants were divided into MetS (+) and MetS (−) groups. MetS (+) were classified into Group 1 (those with 3 MetS criteria), Group 2 (those with 4 MetS criteria) and Group 3 (those with 5 MetS criteria). UHR was compared among the groups. Results Data related to 9637 subjects including 3824 MetS (+) and 5813 MetS (−) were analysed. The mean UHR was significantly higher (p < .001) in the MetS (+) group compared with the MetS (−) group. UHR increased as the MetS severity increased (p < .001). ROC analysis revealed that UHR greater than 9.5% has 89.07% sensitivity and 77.03% specificity in differentiating MetS (−) from MetS (+) subjects. Conclusion Among MASHAD cohort study participants, a significant association between UHR and MetS was found. Furthermore, there is an increase in UHR as the severity of MetS increases. Registration number of MASHAD cohort study: 85134.
Keywords
, high-density lipoprotein, metabolic syndrome, UHR, uric acid
@article{paperid:1102353,
author = {رعنا کلاهی اهری and Mansoori, Amin and تکتم صحرانورد and منیره سادات میری and سارا فیضی and حبیب الله اسماعیلی and مجی غیور مبرهن},
title = {Serum uric acid to high‐density lipoprotein ratio as a novel indicator of inflammation is correlated with the presence and severity of metabolic syndrome: A large‐scale study},
journal = {Endocrinology, Diabetes and Metabolism},
year = {2023},
volume = {6},
number = {6},
month = {August},
issn = {2398-9238},
keywords = {high-density lipoprotein; metabolic syndrome; UHR; uric acid},
}
%0 Journal Article
%T Serum uric acid to high‐density lipoprotein ratio as a novel indicator of inflammation is correlated with the presence and severity of metabolic syndrome: A large‐scale study
%A رعنا کلاهی اهری
%A Mansoori, Amin
%A تکتم صحرانورد
%A منیره سادات میری
%A سارا فیضی
%A حبیب الله اسماعیلی
%A مجی غیور مبرهن
%J Endocrinology, Diabetes and Metabolism
%@ 2398-9238
%D 2023
