Title : ( OPTIMAL STRATEGIES FOR CONTROLLING PARTICLE SIZE IN ANTISOLVENT CRYSTALLIZATION OPERATIONS )
Authors: Seyed Mostafa Nowee Baghban , Ali Abbas , Jose Romagnoli , Pauline Yeo ,
Full TextAbstract
In this paper, a model-based optimal strategy is presented for the control of particle size in antisolvent crystallization. Size is controlled on demand by dynamic optimization using a population balance based model. Knowledge of the ternary solutesolvent- antisolvent equilibrium and crystallization kinetics is crucial in this strategy and are both experimentally identified and incorporated in the model. The optimization is capable of determining the optimal antisolvent feed profile that achieves a desired particle size. Experimental validation of the strategy is carried out and presented herein. Such a strategy stands as a key solution to antisolvent operations ubiquitous in the pharmaceutical and fine chemicals industries.
Keywords
, antisolvent crystallization, optimization, particle size, crystal size distribution, nucleation, growth, parameter estimation, FBRM, feed profile, pharmaceutical
@inproceedings{paperid:1007552,
author = {Nowee Baghban, Seyed Mostafa and Ali Abbas and Jose Romagnoli and Pauline Yeo},
title = {OPTIMAL STRATEGIES FOR CONTROLLING PARTICLE SIZE IN ANTISOLVENT CRYSTALLIZATION OPERATIONS},
booktitle = {8th International Symposium on Dynamics and Control of Process Systems},
year = {2007},
location = {Cancun, Mexico, USA},
keywords = {antisolvent crystallization; optimization; particle size; crystal size distribution;
nucleation; growth; parameter estimation; FBRM; feed profile; pharmaceutical},
}
%0 Conference Proceedings
%T OPTIMAL STRATEGIES FOR CONTROLLING PARTICLE SIZE IN ANTISOLVENT CRYSTALLIZATION OPERATIONS
%A Nowee Baghban, Seyed Mostafa
%A Ali Abbas
%A Jose Romagnoli
%A Pauline Yeo
%J 8th International Symposium on Dynamics and Control of Process Systems
%D 2007
