Title : ( Study of interaction of Spironolactone with Hydroxypropyl-β-Cyclodextrin in aqueous solution and in the solid state )
Authors: امید رجبی , فرنوش طیاری , روشنک سالاری , Sayyed Faramarz Tayyari ,
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Abstract
The interaction between spironolactone (Sp) and hydroxypropyl-b-cyclodextrin (HPbCD) has been investigated in aqueous solution and in the solid state. Phase solubility studies indicate that the complex is formed with possible stoichiometry of 1:1 and association constant of 9806 Mol-1. Differential scanning calorimetry (DSC) gave evidence for the formation of the complex. The details of Sp/HPbCD molecular interaction were analyzed by Fourier transform infrared (FTIR) and Raman spectroscopy. The characterization studies confirmed that the C@O groups of the six-member ring and acetylthio group of Sp interacts with the hydroxyl groups inside and outside the cavity of HPbCD through formation of hydrogen bonds.
Keywords
, Spironolactone; Hydroxypropyl, b, cyclodextrin; FT Raman spectroscopy; FTIR spectroscopy; Complex formation
@article{paperid:1007957,
author = {امید رجبی and فرنوش طیاری and روشنک سالاری and Tayyari, Sayyed Faramarz},
title = {Study of interaction of Spironolactone with Hydroxypropyl-β-Cyclodextrin in aqueous solution and in the solid state},
journal = {Journal of Molecular Structure},
year = {2008},
volume = {878},
month = {May},
issn = {0022-2860},
pages = {78--83},
numpages = {5},
keywords = {Spironolactone; Hydroxypropyl-b-cyclodextrin; FT Raman spectroscopy; FTIR spectroscopy; Complex formation},
}
%0 Journal Article
%T Study of interaction of Spironolactone with Hydroxypropyl-β-Cyclodextrin in aqueous solution and in the solid state
%A امید رجبی
%A فرنوش طیاری
%A روشنک سالاری
%A Tayyari, Sayyed Faramarz
%J Journal of Molecular Structure
%@ 0022-2860
%D 2008
