Levels of heavy metals in air, water and soils have been increasing during the last years, both in urban and petiurban areas. In terms of potential adverse effects on animal and human health, cadmium, lead and arsenic, are amongst the elements that have caused most concern. This is because they are readily transferred through food-chains and are not known to serve any essential biological function (Friberg et al., 1979). Animals are exposed to lead from numerous sources.. The common sources of lead poisoning for ruminants are lead-bearing paints, discarded batteries, and used crankcase oil and pastures contaminated by exhaust of automobiles (Radostits et al., 2007). Lead is considered to be one of the major environmental pollutants and has been incriminated as a cause of accidental poisoning in domestic animals more than any other substance, particularly in cattle, sheep and horses. A number of papers have reviewed specific aspects of lead toxicology in man (Hardy et al., 1971) and animals (Humphreys, 1991; McDowell, 1992). The aim of this study is to investigate the pathological changes due to experimental acute lead poisoning in sheep. six clinically healthy female native breed sheep, aged 1-2 years and weighing between 27-32 kg were selected for the study. For pathomorphological investigation of experimental acute lead poisoning, all the animals were taken 1 g/kg of lead acetate orally. The clinical signs of animals included muscle spasm, excessive response to external stimuli, dullness, loss of appetite, abdominal pain and mild diarrhea. After two weeks, all the animals were euthanized and necropsied.

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