Title : ( Expression of biologically active human factor IX in primary human keratinocytes under the regulation of the keratin 14 gene promoter )
Authors: سیدجواد حسینی , علیرضا زمردی پور , Razieh Jalal , فرزانه صابونی , شراره شجاعی ,
Full TextAbstract
Hemophilia B is an X-linked recessive bleeding disorder affecting about 1 in every 30000 males and is caused by the functional deficiency of coagulation factor IX. The accessibility of keratinocytes and the availability of thechniques for their manipulation have made them appealing for ex vivo gene expression strategies for systemic release of a protein interest. Keratin 14 and keratin 5 are major proteins expressed in keratinocytes. Their corresponding regulatory elements are especially attractive candidates for keratinocyte- mediated gene expression. In the present work, we have used human keratinocytes as hosts for the expression of human FIX under the regulation of the human K14 promoter.
Keywords
, Human factor IX, primary human keratinocyte, keratin 14 gene promoter, Hemophilia B
@inproceedings{paperid:1011174,
author = {سیدجواد حسینی and علیرضا زمردی پور and Jalal, Razieh and فرزانه صابونی and شراره شجاعی},
title = {Expression of biologically active human factor IX in primary human keratinocytes under the regulation of the keratin 14 gene promoter},
booktitle = {8th Iranian Congress of Biochemistry and First International Congress of Biochemistry & Molecular Biology},
year = {2005},
location = {تهران, IRAN},
keywords = {Human factor IX; primary human keratinocyte; keratin 14 gene promoter; Hemophilia B},
}
%0 Conference Proceedings
%T Expression of biologically active human factor IX in primary human keratinocytes under the regulation of the keratin 14 gene promoter
%A سیدجواد حسینی
%A علیرضا زمردی پور
%A Jalal, Razieh
%A فرزانه صابونی
%A شراره شجاعی
%J 8th Iranian Congress of Biochemistry and First International Congress of Biochemistry & Molecular Biology
%D 2005
